Brain Metastasis
of Breast Cancer

This case report shows the possibility to provide earlier accurate diagnosis through Amide Proton Transfer weighted after fluid suppression (F.S. APTw).

Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors

Amide proton transfer-weighted (APTw) MR imaging shows promise as a biomarker of brain tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially among different institutes, and there are no agreed-on standards in the imaging community. 

Fluid suppression in amide proton transfer-weighted (APTw) CEST imaging: New theoretical insights and clinical benefits

Amide proton transfer-weighted (APTw) MRI at 3T provides a unique contrast for brain tumor imaging. However, APTw imaging suffers from hyperintensities in liquid compartments such as cystic or necrotic structures and provides a distorted APTw signal intensity. 

APT weighted imaging
in diffuse gliomas

Amide proton transfer-weighted (APTw) imaging is a non-invasive molecular MRI technique with a wide range of applications in neuroradiology and particularly neuro-oncology imaging. More than 15 years of pre-clinical experiments and clinical studies have demonstrated that APTw metrics are reproducible and reliable, leading to large-scale clinical acceptance.

Current emerging MRI tools for radionecrosis and pseudoprogression diagnosis

Pseudoprogression and radionecrosis are common radiological entities after brain tumor irradiation and are difficult to distinguish from real progression, with major consequences on daily patient care. To date, shortcomings of conventional MRI have been largely recognized but morphological sequences are still used in official response assessment criteria.

Fluid-Suppressed APTw is more accurate than LeakageCorrected rCBV imaging

The distinction between radionecrosis and tumor recurrence is a common diagnostic dilemma, as current advanced multiparametric MRI protocols lack on accuracy. Fluid-Suppressed Amide Proton Transfer weighted (APTw) imaging has strong potentials in brain tumor post-therapeutic assessment. 

CEST MRI provides amide/amine surrogate biomarkers for treatment-naïve glioma sub-typing

Accurate glioma classification affects patient management and is challenging on non- or low-enhancing gliomas. This study investigated the clinical value of different chemical exchange saturation transfer (CEST) metrics for glioma classification and assessed the diagnostic effect of the presence of abundant fluid in glioma subpopulations.

Fast WASABI post-processing: Access to rapid B0 and B1 correction in clinical routine for CEST MRI

CEST MRI methods, such as APT and NOE imaging reveal biomarkers with significant diagnostic potential due to their ability to access molecular tissue information. Regardless of the technique used, CEST MRI data are affected by static magnetic and radiofrequency field inhomogeneities that degrade their contrast. 

Amide Proton Transfer weighted imaging
reveals a rolandic tumor in a pediatric patient

Discovery of a right parietal lesion in a five-year-old
child with local meningeal extension following a convulsive seizure.
The young patient presented a first hyperthermic
convulsive seizure. One month later, he presented another tonic-clonic episode with left hemicorporeal seizure lasting less than 5 minutes. 

APT-CEST imaging in the distinction between radionecrosis & tumor recurrence in brain metastasis

This case report shows the potential added value of Amide Proton Transfer (APT) contrast in the discrimination between radio-induced toxicity lesions
and tumor progression in brain metastatic disease.

Brain: Glioma

Multiparametric MRI in brain tumours is an invaluable
methodology for obtaining in-depth information for the
structural and functional tissue features guiding the
differential diagnosis and assisting the tumour staging.
Each MRI parametric maps provides crucial information
for the different histomolecular tumour substrates,
whereas the ‘tier-like’ interpretation of the combined
structural-functional outputs helps the radiologist to
reach an accurate diagnosis.